1155261-81-6Relevant articles and documents
Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20α-hydroxysteroid dehydrogenase (AKR1C1)
El-Kabbani, Ossama,Scammells, Peter J.,Gosling, Joshua,Dhagat, Urmi,Endo, Satoshi,Matsunaga, Toshiyuki,Soda, Midori,Hara, Akira
, p. 3259 - 3264 (2009)
The first design, synthesis, and evaluation of human 20α- hydroxysteroid dehydrogenase (AKR1C1) inhibitors based on the recently published crystal structure of its ternary complex with inhibitor are reported. While the enzyme-inhibitor interactions observ