115531-70-9

Basic information

• Product Name: (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol
• Synonyms: (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol
• CAS NO: 115531-70-9
• Molecular Formula: C7H16N2O
• Molecular Weight: 144.21474
• Mol File: 115531-70-9.mol

Chemical Properties

• Boiling Point: 247.0±10.0 °C(Predicted)
• Appearance: /
• Density: 1.033±0.06 g/cm3(Predicted)
• PKA: 14.77±0.10(Predicted)
• CAS DataBase Reference: (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol(115531-70-9)
• EPA Substance Registry System: (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol(115531-70-9)

Safety Data

• Hazardous Substances Data: 115531-70-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol is used as a key compound for the development of drugs targeting the central nervous system due to its potential pharmacological properties and biological activity. Its unique structure allows for the creation of novel therapeutic agents that can potentially address various neurological conditions and disorders.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol serves as a valuable starting point for the synthesis of new drug candidates. Its chiral nature and the presence of functional groups make it an ideal candidate for further modification and optimization to enhance its pharmacological properties and improve its therapeutic potential.
Used in Drug Design and Development:
(S)-[1-(2-Aminoethyl)pyrrolidin-2-yl]-methanol is utilized in drug design and development as a structural template for creating new molecules with enhanced efficacy and selectivity. Its unique combination of a hydroxyl group, an amino group, and an ethyl group attached to a four-membered ring structure provides a versatile platform for the development of innovative therapeutic agents.

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 115531-69-6 (S)-2-hydroxymethylpyrrolidin-1-ylacetonitrile 

Relevant articles and documents

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation

Colchicine was modified at the 10-OCH3 position of the C-ring by reaction with heterocyclic amines or commercially available amines to afford a library of target colchicinoids in high yields (62-99%). Molecular modeling revealed that the incorporation of the linker groups led to a reduction in entropy and therefore binding affinity when compared with colchicine. Some colchicinoids were shown to be equicytotoxic with colchicine when evaluated in the DLD-1 colon cancer cells and retained activity in resistant A2780AD or HeLa cells with mutant Class III β-tubulin. Importantly, unlike colchicine, the analogues in this study are amenable for prodrug derivatisation and with potential for tumor-selective delivery.

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells

A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant cells compared to the wild-type cells. Growth curve analysis of the hydroxyethylaminoanthraquinone 8 in the osteosarcoma cell line U-2 OS showed that the cell cycle is not frozen, rather there is a late cell cycle arrest consistent with the action of a DNA-damaging topoisomerase II inhibitor. Accumulative apoptotic events, using time lapse photography, indicate that 8 is capable of fully engaging cell cycle arrest pathways in G2 in the absence of early apoptotic commitment. 8 and its chloropropyl analogue 13 retained significant activity against human A2780/cp70 xenografted tumors in mice.

Pyrrolidin-2-one derivatives having nootropic activity

Pyrrolidin-2-one derivatives of formula I: STR1 wherein X=H, OH, C2 -C7 acyloxy, C1 -C6 alkoxy, cycloalkoxy or phenoxy, n=0 or 1 and m=2 or 3, have a marked nootropic activity.

Pyrrolidin-2-one derivatives having nootropic activity

Pyrrolidin-2-one derivatives of formula I: wherein X = H, OH, C2-C7 acyloxy, C1-C6 alkoxy, cycloalko-xy, aralkoxy or phenoxy, n = 0 or 1 and m = 2 or 3, have a marked nootropic activity.