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1155361-07-1

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1155361-07-1 Usage

General Description

Cytochrome P450 14a-demethylase inhibitor 1i is a chemical compound that acts as an inhibitor of the enzyme cytochrome P450 14a-demethylase. This enzyme is involved in the biosynthesis of sterol molecules, which are essential components of the cell membrane in many organisms, including fungi. By inhibiting this enzyme, the compound can disrupt the synthesis of sterols, leading to impaired cell membrane function and ultimately the death of the fungal cells. This makes Cytochrome P450 14a-demethylase inhibitor 1i a potential candidate for the development of antifungal drugs that target this specific enzyme, offering a new approach to combat fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 1155361-07-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,5,3,6 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1155361-07:
(9*1)+(8*1)+(7*5)+(6*5)+(5*3)+(4*6)+(3*1)+(2*0)+(1*7)=131
131 % 10 = 1
So 1155361-07-1 is a valid CAS Registry Number.

1155361-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(4-bromophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol

1.2 Other means of identification

Product number -
Other names 1-{[(4-bromophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1155361-07-1 SDS

1155361-07-1Downstream Products

1155361-07-1Relevant articles and documents

Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase

Chai, Xiaoyun,Zhang, Jun,Hu, Honggang,Yu, Shichong,Sun, Qingyan,Dan, Zhigang,Jiang, Yuanying,Wu, Qiuye

experimental part, p. 1913 - 1920 (2009/09/30)

Based on the results of computational docking to the active site of the cytochrome P450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. The MIC80 values indicate that compounds 1a-n exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole, while compounds 2a-f, 3a-f showed no activity or only moderate activity against all fungi tested. Noticeably, the MIC value of compounds 1a, 1b and 1g is 64 times lower than that of fluconazole against Microsporum gypseum in vitro. And compounds 1a, 1b and 2b showed 128 times higher activity (with the MIC80 value of 0.0039 μg/mL) than that of fluconazole against Candida albicans and also showed higher activity than that of the other positive controls. Computational docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. In addition, the activity of the compounds would be enhanced when the side chains were shorter.

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