115538-85-7

Basic information

• Product Name: Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)-
• Synonyms: Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)-;7 alpha-hydroxy-3-oxo-4-cholestenoic acid;SATGKQGFUDXGAX-MYWFJNCASA-N
• CAS NO: 115538-85-7
• Molecular Formula: C27H42O4
• Molecular Weight: 430.62
• Mol File: 115538-85-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 590.5°Cat760mmHg
• Flash Point: 324.9°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 2.11E-16mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)-(115538-85-7)
• EPA Substance Registry System: Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)-(115538-85-7)

Safety Data

• Hazardous Substances Data: 115538-85-7(Hazardous Substances Data)

Usage

Description

Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)is a cholestanoid, which is a type of steroid. It is specifically a cholest-4-en-26-oic acid substituted by an alpha-hydroxy group at position 7 and an oxo group at position 3. Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)serves as an intermediate metabolite in the synthesis of bile acids and is also a metabolite of 27-OHC.

Uses

Used in Pharmaceutical Industry:
Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)is used as a biomarker for assessing the permeability of the blood-brain barrier. Its presence indicates the ability of certain substances to cross this barrier, which is crucial for the development of drugs targeting the central nervous system.
Used in Metabolic Research:
Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)is used as a research tool in the study of bile acid synthesis and metabolism. Understanding its role in the metabolic pathway can provide insights into the regulation of cholesterol and bile acid homeostasis, which are essential for maintaining overall health.
Used in Diagnostic Applications:
As a metabolite of 27-OHC, Cholest-4-en-26-oic acid, 7-hydroxy-3-oxo-, (7alpha)can be utilized in diagnostic tests to monitor and evaluate the metabolic state of an individual, particularly in relation to cholesterol and bile acid metabolism. This can be helpful in identifying potential health risks and guiding treatment strategies.

InChI:InChI=1/C27H42O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h14,16-17,20-24,29H,5-13,15H2,1-4H3,(H,30,31)/t16-,17?,20-,21+,22+,23-,24+,26+,27-/m1/s1