115540-77-7Relevant academic research and scientific papers
Copper-catalyzed domino reaction of carbodiimides and benzoic acid derivatives for the synthesis of quinazolinediones
Duangjan, Chanikan,Rukachaisirikul, Vatcharin,Saithong, Saowanit,Kaeobamrung, Juthanat
, p. 3537 - 3540 (2018/08/29)
Quinazolinediones were obtained from 2-iodobenzoic acids and carbodiimide derivatives under mild reaction conditions via a copper-catalyzed domino reaction. The absence of an external base was essential to avoid the generation of amide by-products. Both alkyl- and aryl-substituted carbodiimides gave the corresponding quinazolinediones. However, the use of aryl-substituted carbodiimides resulted in low yields due to an undesired elimination process.
Synthesis of 3-Aryl-1H,3H-quinazolin-2,4-diones and Their 2-Thio Analogues
Reddy, Ch. K.,Reddy, P. S. N.,Ratnam, C. V.
, p. 882 - 883 (2007/10/02)
3-Aryl-(2-thio)-1H,3H-quinazolin-2,4-diones (3, R= H, CH3, C2H5; X= O, S) have been obtained by the fusion of isatoic anhydrides (1, R= H, CH3, C2H5) with aryliso(thio)cyanates (2, X= O, S).
