115543-07-2

Usage

Uses

Used in Catalyst Applications:
[Ru(η^6-p-cymene)Cl2(DMSO)] is utilized as a catalyst in various organic transformations, such as hydrogenation, metathesis, and oxidation reactions. Its unique structure and reactivity make it a valuable tool in synthetic chemistry and catalysis.
Used in Chemical Synthesis Industry:
In the chemical synthesis industry, [Ru(η^6-p-cymene)Cl2(DMSO)] is used as a catalyst to facilitate numerous chemical reactions, enhancing the efficiency and selectivity of the processes. Its application contributes to the development of new compounds and materials with potential applications in various fields, such as pharmaceuticals, materials science, and environmental chemistry.
Used in Research and Development:
[Ru(η^6-p-cymene)Cl2(DMSO)] is also employed in research and development settings, where it is used to study the fundamental aspects of catalysis and reaction mechanisms. This knowledge can be applied to design more efficient and sustainable chemical processes, as well as to develop new catalysts with improved performance.

Upstream product

• 67-68-5 dimethyl sulfoxide 

Relevant academic research and scientific papers

DMSO-mediated ligand dissociation: Renaissance for biological activity of N-heterocyclic-[Ru(η6-arene)Cl2] drug candidates

Slipped under the radar? 1HNMR spectroscopic examination revealed that [Ru(η6-arene)Cl2(L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes. Copyright

Conjugating Biotin to Ruthenium(II) Arene Units via Phosphine Ligand Functionalization

Two-step functionalization of 4-diphenylphosphino benzoic acid with biotin afforded 2-(biotinyloxy)ethyl 4-(diphenylphosphanyl)benzoate (LP), that was subsequently used to synthesize the Ru(II) arene complexes [RuCl2(η6-p-cymene)(LP)] (1), [Ru(C2O4)(η6-p-cymene)(LP)] (2) and [Ru(curc)(η6-p-cymene)(LP)]NO3 ([3]NO3), the latter incorporating curcumin (curcH) as an additional bioactive fragment. [Ru(curc)(η6-p-cymene)(PPh3)]NO3 ([4]NO3) was also prepared as a reference compound. Compounds 2 and [3]NO3 exhibited excellent stability in water/DMSO solution while being slowly activated in the cell culture medium over 72 hours. Together with LP, they were therefore assessed for their antiproliferative activity towards a panel of cancer cell lines, with different levels of biotin transporter expression. The apparent affinity of the compounds towards avidin varies, and their antiproliferative activity does not correlate with biotin transporter expression, although it is systematically enhanced when biotin-free cell culture medium is used.