115545-60-3 Usage
Property
Different sources of media describe the Property of 115545-60-3 differently. You can refer to the following data:
1. Synthetic chemical compound
2. Selective antagonist of the excitatory amino acid transporter subtype 2 (EAAT2)
3. Used as a research tool
4. Investigates the role of EAAT2 in regulating extracellular levels of glutamate
5. Inhibits EAAT2
6. Increases levels of glutamate in the synapse
7. Implicated in neurological disorders such as epilepsy, ischemia, and neurodegenerative diseases
8. Studied for potential therapeutic effects in treating neurological disorders
9. Modulates glutamate levels in the brain
Check Digit Verification of cas no
The CAS Registry Mumber 115545-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,5,4 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 115545-60:
(8*1)+(7*1)+(6*5)+(5*5)+(4*4)+(3*5)+(2*6)+(1*0)=113
113 % 10 = 3
So 115545-60-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H21NO4/c15-11(14(17)18)6-12(16)19-13-9-2-7-1-8(4-9)5-10(13)3-7/h7-11,13H,1-6,15H2,(H,17,18)/t7?,8?,9?,10?,11-,13?/m1/s1
115545-60-3Relevant articles and documents
Amino Acids and Peptides. Part 19. Synthesis of β-1-and β-2-Adamantyl Aspartates and their Evaluation for Peptide Synthesis
Okada, Yoshio,Iguchi, Shin
, p. 2129 - 2136 (2007/10/02)
β-1-and β-2-Adamantyl aspartates have been synthesized and their properties examined.Altough the 1-Ada group is labile to TFA, the 2-Ada group is unaffected during TFA treatment, but easily removable by methanesulphonic acid (MSA) at room temperature within 5 min.Both groups are unaffected by treatment with 55percent piperidine under conditions which easily cleave the fluoren-9-ylmethoxycarbonyl (Fmoc) group from α-amino group.Both groups can suppress aspartimide formation as a side reaction under acidic and basic conditions during the synthesis of aspartyl peptides. β-1-or β-2-Adamantyl aspartates may be applicable to solid-phase peptide synthesis in combination with Fmoc or Boc as an Nα-protecting group, respectively.Some properties of the aspartimide moiety are described.
