115563-43-4Relevant academic research and scientific papers
RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines
Tashiro, Takuya,Hongo, Naomi,Nakagawa, Ryusuke,Seino, Ken-ichiro,Watarai, Hiroshi,Ishii, Yasuyuki,Taniguchi, Masaru,Mori, Kenji
, p. 8896 - 8906 (2008/12/23)
RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 (1) with a sulfonamide linkage instead of an amide bond, were synthesized to examine their bioactivity for mouse natural killer (NK) T cells. RCAI-17, 22, 24-26, 29, 31, 34-36, and 8
Sex pheromones of the hair crab Erimacrus isenbeckii. II. Synthesis of ceramides
Asai,Fusetani,Matsunaga
, p. 1210 - 1215 (2007/10/03)
To confirm their structures and to assess the pheromonal activity, novel ceramides, possible sex pheromones of the hair crab Erimacrus isenbeckii, were synthesized from D-galactose. The synthetic ceramides were identical with the natural ceramides.
Structure-activity relationship of α-galactosylceramides against b16- bearing mice
Morita,Motoki,Akimoto,Natori,Sakai,Sawa,Yamaji,Koezuka,Kobayashi,Fukushima
, p. 2176 - 2187 (2007/10/02)
Agelasphin-9b, (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-16-methyl-2-[N- ((R)-2-hydroxytetracosanoyl)-amino]-1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S,4R)-1-O-(α- D-galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol, was selected as a candidate for clinical application.
Total Synthesis of (2S,3S,4R)-N-Tetracosanoyl-2-amino-1,3,4-octadecanetriol, a Ceramide Part of Wheat Flour Glycosyl Ceramides
Koike, Katsuya,Nakahara, Yoshiaki,Ogawa, Tomoya
, p. 663 - 667 (2007/10/02)
The synthesis of (2S,3S,4R)-N-tetracosanoyl-2-amino-1,3,4-octadecanetriol (5) was achieved in eight steps in a 23 percent overall yield starting from 3,4,6-tri-O-benzyl-D-galactopyranose (6), and then ceramide 5 was converted to (2S,3S,4R)-3,4-di-O-benzoy
