1155701-10-2Relevant academic research and scientific papers
Replacing the 2′-oxygen with an exocyclic methylene group reverses the stabilization effects of α-l-LNA
Seth, Punit P.,Allerson, Charles R.,Berdeja, Andres,Swayze, Eric E.
, p. 588 - 591 (2011)
The synthesis and hybridization properties of an α-l-LNA analog where the 2′-oxygen atom is replaced with an exocyclic methylene group is reported. Contrary to the β-d series where the exocyclic methylene group is extremely well tolerated, this group was
