1155800-45-5

Basic information

• Product Name: N-[4-Cyano-3-(trifluoroMethyl)phenyl]-2,2,2-trifluoroacetaMide
• Synonyms: N-[4-Cyano-3-(trifluoroMethyl)phenyl]-2,2,2-trifluoroacetaMide;4-Cyano-3-(trifluoromethyl)trifluoroacetanilide
• CAS NO: 1155800-45-5
• Molecular Formula: C₁₀H₄F₆N₂O
• Molecular Weight: 282.1419792
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1155800-45-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-[4-Cyano-3-(trifluoroMethyl)phenyl]-2,2,2-trifluoroacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-Cyano-3-(trifluoroMethyl)phenyl]-2,2,2-trifluoroacetaMide(1155800-45-5)
• EPA Substance Registry System: N-[4-Cyano-3-(trifluoroMethyl)phenyl]-2,2,2-trifluoroacetaMide(1155800-45-5)

Safety Data

• Hazardous Substances Data: 1155800-45-5(Hazardous Substances Data)

Usage

Uses

N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,2,2-trifluoroacetamide, is an intermediate in the synthesis of scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile.

Upstream product

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1155800-48-8 N-(4-cyano-2-nitro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide 
• 1155800-50-2 N-(4-cyano-2,6-dinitro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide 

Relevant articles and documents

An efficient synthetic process for scale-up production of 4,5-diamino-2- (trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine

Starting from 4-amino-2-(trifluoromethyl)benzonitrile (6), an efficient and nonchromatographic process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)- benzonitrile (1) in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline (7) that afforded 5-bromo-3- (trifluoromethyl)benzene-1,2-diamine (5) in 81% overall yield and 99% HPLC area% purity.