1155846-87-9Relevant academic research and scientific papers
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
C?té, Bernard,Burch, Jason D.,Asante-Appiah, Ernest,Bayly, Chris,Bédard, Leanne,Blouin, Marc,Campeau, Louis-Charles,Cauchon, Elizabeth,Chan, Manuel,Chefson, Amandine,Coulombe, Nathalie,Cromlish, Wanda,Debnath, Smita,Deschênes, Denis,Dupont-Gaudet, Kristina,Falgueyret, Jean-Pierre,Forget, Robert,Gagné, Sébastien,Gauvreau, Danny,Girardin, Melina,Guiral, Sébastien,Langlois, Eric,Li, Chun Sing,Nguyen, Natalie,Papp, Rob,Plamondon, Serge,Roy, Amélie,Roy, Stéphanie,Seliniotakis, Ria,St-Onge, Miguel,Ouellet, Stéphane,Tawa, Paul,Truchon, Jean-Fran?ois,Vacca, Joe,Wrona, Marc,Yan, Youwei,Ducharme, Yves
, p. 917 - 922 (2014/02/14)
The optimization of a novel series of non-nucleoside reverse transcriptase inhibitors (NNRTI) led to the identification of pyridone 36. In cell cultures, this new NNRTI shows a superior potency profile against a range of wild type and clinically relevant,
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 18, (2011/10/13)
Heteroaromatic compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula I and their pharmaceutically acceptable salt
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 74-75, (2009/06/27)
Heteroaromatic compounds of Formula (I), are HIV reverse transcriptase inhibitors, wherein ring A is: (ii-a), (ii-b), (ii-c), (ii-d), or (ii-e); and wherein n, L, M, U, X, Y, Z, RE, RF, R1, R2A, R2B,
