115585-33-6Relevant articles and documents
Malonic ester amide synthesis: An efficient methodology for synthesis of amides
Mahajan, Pankaj S.,Mahajan, Jyoti P.,Mhaske, Santosh B.
, p. 2508 - 2516 (2013/07/25)
A general methodology malonic ester amide synthesis has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Copyright
