1155975-70-4Relevant academic research and scientific papers
Three-component tandem-intramolecular hydroamination reactions in one pot involving indoles, 2-aminobenzyl alcohols, and 2-alkynylbenzaldehydes: Consecutive 7-endo-trig and electrophilic 6-endo-dig cyclizations
Samala, Srinivas,Saifuddin, Mohammad,Mandadapu, Anil K.,Kundu, Bijoy
, p. 3797 - 3806 (2013)
A one-pot protocol for the synthesis of indole-based annulated polyheterocycles involving consecutive 7-endo-trig and electrophilic 6-endo-dig cyclizations is described. The reaction proceeds initially through annulation of 5-methoxyindole, 2-amino benzyl
Acid mediated coupling of aliphatic amines and nitrosoarenes to indoles
Roy, Subhra Kanti,Purkait, Anisha,Aziz, Sk Md Tarik,Jana, Chandan K.
, p. 3167 - 3170 (2020/03/23)
Traditionally, amines react with nitrosoarenes to provide the corresponding imines or azo compounds. Herein, we report an acid mediated annulation reaction of aliphatic amines and nitrosoarenes to provide indole derivatives. The elusive direct annulation of aliphatic amines and nitrosoarenes via simultaneous C-C and C-N bond formation was achieved under metal free conditions. This conceptually novel method for indole synthesis does not require pre-functionalization steps for the new C-C and C-N bond formation. The method has been applied for an elegant synthesis of nor-neocryptolepine and neocryptolepine.
Application of 7-endo-trig Pictet-Spengler cyclization to the formation of the benzazepine ring: Synthesis of benzazepinoindoles
Sharma, Sudhir K.,Sharma, Sunil,Agarwai, Piyusli K.,Kundu, Bijoy
experimental part, p. 1309 - 1312 (2009/07/26)
The preparation of benzazepinoindoles, fused heterocycles with a benzazepine moiety, was accomplished through an intramolecular 7-endo-tring Pictet-Spengler cyclization. The precursors comprising C-3- or C-2-linked o-aminobenzyl-indoles required for the c
