115648-73-2

Upstream product

• 107-13-1 acrylonitrile 
• 117653-40-4 (2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 57653-35-7 (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl 
• 115545-79-4 6-(benzyloxycarbonyl)-3-cyano-4-chloro-6-azabicyclo<3.2.1>oct-3-ene 
• 115545-76-1 6-(benzyloxycarbonyl)-3-cyano-4-keto-6-azabicyclo<3.2.1>octane 
• 117653-41-5 (S)-4-(2-Cyano-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 186581-53-3 diazomethane 
• 115545-74-9 Cbz-4-(2-cyanoethyl)-Pro-OMe 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 

Downstream Products

• 117708-24-4 (1R,5R)-6-(benzyloxycarbonyl)-3-cyano-4-keto-6-azabicyclo<3.2.1>octane 
• 117708-26-6 (1R,5R)-4-Chloro-3-cyano-6-aza-bicyclo[3.2.1]oct-3-ene-6-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Amino Acid Derivatives That Stabilize Secondary Structures of Polypeptides. 4. Practical Synthesis of 4-(Alkylamino)-3-cyano-6-azabicyclooct-3-enes (Ben Derivatives) as γ-Turn Templates

A practical synthesis of the conformationally restricted amino acid analogue methyl N-oct-2-enyl>>-L-alaninate (12ab) from 4-hydroxyproline is described.Blocking and Barton cyanoethylation generates N-(

AMINO ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES-IV. PRACTICAL SYNTHESIS OF 4-ALKYLAMINO-3-CYANO-6-AZABICYCLOOCT-3-ENES (BEN DERIVATIVES) AS γ-TURN TEMPLATES

Ben derivatives have been prepared in five steps from 4-hydroxyproline by Barton cyanoethylation, ring closure, and derivitization.Proof of absolute configuration and practical synthesis of pure Ben enantiomers are described.