1156491-03-0

Basic information

• Product Name: (4R)-3-{-[(1S,2S)-2-(3-chlorophenyl)cyclopropyl]carbonyl}-4-phenyl-1,3-oxazolidin-2-one
• Synonyms: (4R)-3-{-[(1S,2S)-2-(3-chlorophenyl)cyclopropyl]carbonyl}-4-phenyl-1,3-oxazolidin-2-one
• CAS NO: 1156491-03-0
• Molecular Weight: 341.794
• Mol File: 1156491-03-0.mol

Chemical Properties

• CAS DataBase Reference: (4R)-3-{-[(1S,2S)-2-(3-chlorophenyl)cyclopropyl]carbonyl}-4-phenyl-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-3-{-[(1S,2S)-2-(3-chlorophenyl)cyclopropyl]carbonyl}-4-phenyl-1,3-oxazolidin-2-one(1156491-03-0)
• EPA Substance Registry System: (4R)-3-{-[(1S,2S)-2-(3-chlorophenyl)cyclopropyl]carbonyl}-4-phenyl-1,3-oxazolidin-2-one(1156491-03-0)

Safety Data

• Hazardous Substances Data: 1156491-03-0(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 

Downstream Products

• 515179-15-4 (+)-(1S,2S)-2-(3-chlorophenyl)cyclopropanecarboxylic acid 

Relevant articles and documents

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors

A series of trans-2-aryl-cyclopropylamine derived compounds were synthesized and evaluated their biological activities against DPP-IV. The structure-activity relationships (SAR) led to the discovery of novel series of DPP-IV inhibitors, having IC50 values of 100 nM with excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. The studies identified a potent and selective DPP-IV inhibitor 24b, which exhibited the ability to both significantly inhibit plasma DPP-IV activity in rats and improve glucose tolerance in lean mice and diet induced obese mice.