115651-31-5Relevant academic research and scientific papers
Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
-
Page/Page column 34, (2010/02/14)
The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
Synthesis of Benzoic Acid Derivatives from 3-Ethoxymethylene-2,4-alkanediones and Malononitrile
Schmidt, Hans-Werner,Kores, Margarete
, p. 1001 - 1004 (2007/10/02)
Reaction of the 3-ethoxymethylene-2,4-alkanediones 1a-c with malononitrile (2) gives the benzonitrile derivatives 3a-c.Compounds 4a-d are obtained by acid or basic hydrolysis of the nitrile group of 3a-c, Sandmeyer reaction leads to the halogenated benzonitriles 5a-f.Compounds 6a,b are available from 3a and O-ethyl- and O-allylhydroxylamine hydrochloride.
