115654-59-6

Basic information

• Product Name: BOC-L-LEU-NITRILE
• Synonyms: BOC-L-LEU-NITRILE;Boc-Leu-Nitrile;Carbamic acid, N-[(1S)-1-cyano-3-methylbutyl]-, 1,1-dimethylethyl ester;(S)-(1-Cyano-3-methylbutyl)carbamic acid tert-butyl ester;Carbamic acid, (1-cyano-3-methylbutyl)-, 1,1-dimethylethyl ester, (S)-;Carbamic acid, [(1S)-1-cyano-3-methylbutyl]-, 1,1-dimethylethyl ester (9CI);(S)-N-Boc-Leucinenitrile;tris(tert-butyl N-[(1S)-1-cyano-3-Methylbutyl]carbaMate)
• CAS NO: 115654-59-6
• Molecular Formula: C11H20N2O2
• Molecular Weight: 212.291
• Mol File: 115654-59-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 318.935 °C at 760 mmHg
• Flash Point: 146.687 °C
• Appearance: White to off-white powder
• Density: 0.98 g/cm³
• Vapor Pressure: 0.00035mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: BOC-L-LEU-NITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-LEU-NITRILE(115654-59-6)
• EPA Substance Registry System: BOC-L-LEU-NITRILE(115654-59-6)

Safety Data

• Hazardous Substances Data: 115654-59-6(Hazardous Substances Data)

Usage

General Description

BOC-L-LEU-NITRILE, also known as t-butyloxycarbonyl-L-leucine nitrile, is a chemical compound that belongs to the category of amino acid derivatives. It is commonly used as a building block in the synthesis of peptides and pharmaceutical compounds. BOC-L-LEU-NITRILE is known for its ability to act as a strong inhibitor of several proteases, making it a valuable tool in biochemistry and drug discovery research. BOC-L-LEU-NITRILE is also used in the production of specialty chemicals and as a reagent in organic synthesis. It is important to handle BOC-L-LEU-NITRILE with caution, as it may cause irritation to the skin and eyes, and should only be used in a well-ventilated area with proper personal protective equipment.

InChI:InChI=1/C11H20N2O2/c1-8(2)6-9(7-12)13-10(14)15-11(3,4)5/h8-9H,6H2,1-5H3,(H,13,14)/t9-/m0/s1

Upstream product

• 70533-96-9 N-tert-butoxycarbonyl-(L)-leucinamide 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 75899-20-6 (C₅H₉O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅) 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 433335-07-0 [3-methyl-1-(toluene-4-sulfonyl)-butyl]-carbamic acid tert-butyl ester 

Downstream Products

• 105356-41-0 (S)-1-cyano-3-methyl-butylamine 
• 115654-40-5 (S)-(-)-1,1-dimethylethyl <1-(aminomethyl)-3-methylbutyl>carbamate 

Relevant articles and documents

Design, synthesis and cytotoxic evaluation of a library of oxadiazole-containing hybrids

The development of hybrid compounds led to the discovery of new pharmacologically active agents for some of the most critical diseases, including cancer. Herein, we describe a new series of oxadiazole-containing structures designed by a molecular hybridiz

Isoselenocyanates derived from Boc/Z-amino acids: Synthesis, isolation, characterization, and application to the efficient synthesis of unsymmetrical selenoureas and selenoureidopeptidomimetics

Isoselenocyanates derived from Boc/Z-amino acids are prepared by the reaction of the corresponding isonitriles with selenium powder in presence of triethylamine at reflux. The utility of these new classes of isoselenocyanates in the preparation of selenoureidodipeptidomimetics possessing both amino as well as carboxy termini has been accomplished. The 1H NMR analysis confirmed that the protocol involving the conversion of isonitriles to isoselenocyanates and their use as coupling agents in assembling selenoureido derivatives is free from racemization.

Phase transfer catalyzed enantioselective strecker reactions of α-amido sulfones with cyanohydrins

A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of α-amino nitriles from α-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed