1156540-92-9Relevant academic research and scientific papers
ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE
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Page/Page column 48; 50; 62, (2010/09/03)
Cobalt(ll) complexes of the D2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corresponding cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantio-selectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides through mild reactions with a wide range of amine derivatives, including unprotected peptides and amino sugars
Asymmetric Co(II)-catalyzed cyclopropanation with succinimidyl diazoacetate: General synthesis of chiral cyclopropyl carboxamides
Ruppel, Joshua V.,Gauthier, Ted J.,Snyder, Nicole L.,Perman, Jason A.,Zhang, X. Peter
supporting information; experimental part, p. 2273 - 2276 (2009/10/02)
[Co(P1)] is an effective catalyst for asymmetric cyclopropanation with succinimidyl diazoacetate. The Co(II)-catalyzed reaction is suitable for various olefins, providing the desired cyclopropane succinimidyl esters in high yields and excellent diastereo-
