1156543-91-7Relevant academic research and scientific papers
Synthesis and antioxidant of activity of alkyl nitroderivatives of hydroxytyrosol
Gallardo, Elena,Palma-Valdés, Rocío,Sarriá, Beatriz,Gallardo, Irene,De La Cruz, José P.,Bravo, Laura,Mateos, Raquel,Espartero, José L.
, (2016/06/15)
A series of alkyl nitrohydroxytyrosyl ether derivatives has been synthesized from free hydroxytyrosol (HT), the natural olive oil phenol, in order to increase the assortment of compounds with potential neuroprotective activity in Parkinson's disease. In t
Easy eco-friendly phenonium ion production from phenethyl alcohols in dimethyl carbonate
Barontini,Proietti Silvestri,Nardi,Bovicelli,Pari,Gallucci,Spezia,Righi
supporting information, p. 5004 - 5006 (2013/08/28)
An efficient and simple one-pot procedure for selective etherification of 2-aryl-ethylalcohols has been achieved through Amberlyst 15-catalyzed reaction in dimethyl carbonate (DMC). Moreover, the polymer catalyst could be recovered and reused with no effect on its activity. The reaction mechanism involves the formation of phenonium ion which has been demonstrated by a C-C bond forming reaction. Theoretical studies are in agreement with and thus explain experimental results.
Preparation and antioxidant activity of tyrosyl and homovanillyl ethers
Madrona,Pereira-Caro,Bravo,Mateos,Espartero
, p. 1169 - 1178 (2012/05/05)
Preparation of tyrosyl and homovanillyl lipophilic derivatives was carried out as a response to the food industry's increasing demand for new synthetic lipophilic antioxidants. Tyrosyl and homovanillyl ethers were synthesized in high yields by a three-step procedure starting from tyrosol (Ty) and homovanillic alcohol (HMV). The antioxidant activity of these new series of alkyl tyrosyl and homovanillyl ethers was evaluated by the Rancimat test in a lipophilic food matrix and by the FRAP, ABTS and ORAC assays and compared to free Ty and HMV as well as two antioxidants widely used in the food industry, butylhydroxytoluene (BHT) and α-tocopherol. The results pointed out the higher activity of homovanillyl series in comparison with tyrosyl series with all the assayed methods. However, while both synthetic series were less antioxidant than BHT and α-tocopherol in a lipophilic matrix after their Rancimat test evaluation, homovanillyl alkyl ethers showed the best reducing power and radical scavenging activity of all evaluated compounds. This batch of synthetic lipophilic compounds, derived from biologically active compounds such as Ty and HMV, provide interesting and potentially bioactive compounds.
