115656-50-3Relevant academic research and scientific papers
Selective β3-adrenergic agonists of brown adipose tissue and thermogenesis. 2. [4-[2-[(2-Hydroxy-3- phenoxypropyl)amino]ethoxy]phenoxy]acetamides
Howe,Rao,Holloway,Stribling
, p. 1759 - 1764 (2007/10/02)
The ester methyl [4-[2-[(2-hydroxy-3- phenoxypropyl)amino]ethoxy]phenoxy]acetate (1) (R1 = OMe) had previously been identified as the most interesting member of a series of selective β3- adrenergic agonists of brown adipose tissue an
Amide derivatives
-
, (2008/06/13)
The invention concerns novel phenoxyacetic acid amide derivatives of the formula I (and pharmaceutically acceptable salts thereof) in which R1 is hydrogen or fluoro, R2 is phenyl, cycloalkyl, alkyl or alkenyl as defined herein, and R3 is hydrogen, methyl or ethyl, or R2 and R3 together form polymethylene as defined herein. The invention also includes pharmaceutical compositions containing the amide derivatives, means for the manufacture of the said derivatives and for their use in the treatment of obesity and related conditions and/or in the manufacture of novel medicaments.
