115698-06-1

Upstream product

• 75073-15-3 ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate 
• 590-17-0 cyanomethyl bromide 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 70032-30-3 diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate 
• 367-21-5 3-chloro-4-fluorophenylamine 

Relevant academic research and scientific papers

Synthesis and in vitro antiplasmodial activities of fluoroquinolone analogs

Fluoroquinolone analogs were synthesized by simple alkylation followed by click chemistry and evaluated for their antimalarial in vitro against chloroquine sensitive strain of Plasmodium falciparum while ciprofloxacin was used as standard. Our results showed that the compound 12 was found most active with IC50 value of 1.33 μg/mL while ciprofloxacin showed IC 50 = 8.81 μg/mL. Therefore, screening of either known or unknown quinolone/fluoroquinolone analogs are worthwhile to find more potent antimalarial drugs which might prove useful in the treatment of mild or severe malaria in human either alone or in combination with existing antimalarial drugs.

The Synthesis of 1-quinolones. The Reactivity of the Methylene Bridge at Position-1 and its Involvement in the Formation of a Stable Carbon-Nitrogen Ylid.

A series of 7-chloro-1,4-dihydro-6-fluoro-1--4-oxoquinoline carboxylic esters 5 has been prepared.Dehydration of the intermediates 4-hydroxythiazolines 4 with trifluoroacetic anhydride resulted in the formation of a ylid 11.Evidence for this was obtained by the X-ray analysis of the analogous product obtained in reactions carried out with 4-pyridone.