115700-52-2

Upstream product

• 7763-16-8 N²-benzyloxycarbonyl-L-glutamine-(4-nitro-phenyl ester) 
• 122751-45-5 H-Val-Val-Ala-Ala-OMe 
• 122751-40-0 Z-Gln-OPyCl 
• 62104-70-5 Z-Val-Ala-Ala-OMe 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 41445-88-9 Z-Val-OCO₂ⁱBu 
• 108072-27-1 H-Val-Ala-Ala-OMe 
• 2483-51-4 N-[(benzyloxy)carbonyl]-L-alanyl-L-alanine methyl ester 
• 2650-64-8 Cbz-L-Gln 
• 41036-19-5 L-alanyl-alanine methylester hydrochloride 
• 117507-21-8 Z-Val-Val-Ala-Ala-OMe 
• 117507-20-7 Z-Val-Ala-N₃ 
• 75707-26-5 Z-Val-Ala-NHNH₂ 

Relevant academic research and scientific papers

Amino acids and peptides. XXIII. Synthesis of N alpha-protected amino acid 6-chloro-2-pyridyl esters and their evaluation for peptide synthesis.

6-Chloro-2-pyridyl esters (OPyCl) of N alpha-benzyloxycarbonyl and tert-butyloxycarbonylamino acids were synthesized by the N,N'-dicyclohexylcarbodiimide (DCC) method from the acids and 6-chloro-2-hydroxypyridine in dimethylformamide (DMF). The reactivity of the 6-chloro-2-pyridylester with amino group is much higher than that of the corresponding 2-pyridyl ester (OPy) and p-nitrophenyl esters (ONp) in dioxane and DMF, and a peptide bond is formed without acylation at the side chain hydroxyl group of amino acids. Z-Asp(OBzl)-OPyCl reacted with amino acid methyl esters in dioxane to give the corresponding dipeptide without any detectable aspartimide formation.