115730-34-2Relevant academic research and scientific papers
Synthesis and resolution of DHCGA, a new conformationally rigid 3,4-dehydroglutamic acid analogue
Trigalo, Francois,Acher, Francine,Azerad, Robert
, p. 5203 - 5212 (2007/10/02)
(±)-1-amino-2-cyclohexene-1,3-dicarboxylic acid (DHCGA),an unsaturated cyclic analogue of glutamic acid, was prepared from 3-carboxy-4-cyclohexenone by a Bucherer-Bergs reaction. Resolution was performed through coupling with L-leucine and separation of the resulting diastereoisomeric dipeptides. Spectral data, including optical rotation and circular dichroism of both enantiomers of DHCGA are reported.
CHEMOENZYMATIC SYNTHESIS OF CONFORMATIONALLY RIGID GLUTAMIC ACID ANALOGUES
Trigalo, F.,Buisson, D.,Azerad, R.
, p. 6109 - 6112 (2007/10/02)
All stereomers of cyclohexane cyclopentane-derived analogues of glutamic acid have been synthesized from the corresponding 3-keto-cycloalkyl carboxylic acid esters by a combination of microbial steps and standard chemical methods.
