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115787-50-3

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115787-50-3 Usage

Chemical Properties

Brown Solid

Uses

Intermediate in the preparation of Salmeterol (S090100).

Check Digit Verification of cas no

The CAS Registry Mumber 115787-50-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,7,8 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 115787-50:
(8*1)+(7*1)+(6*5)+(5*7)+(4*8)+(3*7)+(2*5)+(1*0)=143
143 % 10 = 3
So 115787-50-3 is a valid CAS Registry Number.
InChI:InChI=1S/C9H7BrO3/c10-4-9(13)6-1-2-8(12)7(3-6)5-11/h1-3,5,12H,4H2

115787-50-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(2-Bromoacetyl)-2-hydroxybenzaldehyde

1.2 Other means of identification

Product number -
Other names 5-(2-bromoacetyl)-2-hydroxybenzaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115787-50-3 SDS

115787-50-3Relevant articles and documents

Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities

Chaudhuri, Amrita,Venkatesh, Yarra,Jena, Bikash Chandra,Behara, Krishna Kalyani,Mandal, Mahitosh,Singh, N.D. Pradeep

, p. 8800 - 8805 (2019)

Hydrogen persulfide (H2S2) plays an important role in sulfur-based redox signaling mechanisms. Herein, we developed a visible light activated ESIPT based H2S2 donor using a p-hydroxyphenacyl phototrigger. The unique feature of the designed H2S2 donor system is the ability to monitor the H2S2 release in real time through a non-invasive fluorescence color change approach, with the color changing from green to blue. Next, we demonstrated the detection and quantification of H2S2 using a fluorescein based "turn-on" fluorescent probe. Furthermore, in vitro studies of the designed H2S2 donor demonstrated the real-time monitored H2S2 release and cytoprotective ability in the highly oxidizing cellular environment of MDA-MB-468 cells.

Tetraphenylethylene conjugated: P -hydroxyphenacyl: Fluorescent organic nanoparticles for the release of hydrogen sulfide under visible light with real-time cellular imaging

Parthiban,Pavithra,Reddy, L. Vinod Kumar,Sen, Dwaipayan,Samuel, Melvin S.,Singh, N. D. Pradeep

, p. 7903 - 7909 (2018)

Hydrogen sulfide (H2S) behaves like a two-edged sword, at low concentrations it has beneficial and cytoprotective effects, while at higher concentrations it exhibits toxicity. Hence there is a keen interest in developing light responsive H2S donors with a spatio-temporal controlled release. Herein, we report visible light activatable tetraphenylethylene conjugated p-hydroxyphenacyl (TPE-pHP-H2S) nanoparticles for the release of hydrogen sulfide (H2S) with a real time monitoring ability. Our newly designed photoresponsive single component organic nanoparticle based H2S donor is built by integrating the tetraphenylethylene (TPE) moiety and p-hydroxyphenacyl (pHP) group so that it can display both aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT) properties. Aggregation-induced emission enhancement was exhibited by our TPE-pHP-H2S NP donor, which was then explored for the cellular imaging application. The ESIPT by the pHP moiety provided unique advantages to our TPE-pHP-H2S NP donor which include (i) the excitation wavelength extended to >410 nm (ii) a large Stokes shift (iii) a low inner filter effect and (iv) real-time monitoring of H2S release by a simple fluorescent colour change. In vitro studies showed that the TPE-pHP-H2S NP donor presents excellent properties like real-time monitoring, photoregulated H2S release and biocompatibility.

A p-Hydroxyphenacyl-Benzothiazole-Chlorambucil Conjugate as a Real-Time-Monitoring Drug-Delivery System Assisted by Excited-State Intramolecular Proton Transfer

Barman, Shrabani,Mukhopadhyay, Sourav K.,Biswas, Sandipan,Nandi, Surajit,Gangopadhyay, Moumita,Dey, Satyahari,Anoop, Anakuthil,Singh, N.D. Pradeep

, p. 4194 - 4198 (2016)

Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of theranostics, because of two major limitations: Its excitation wavelength is below 400 nm, and it is nonfluorescent. We have overcome these limitations by incorporating a 2-(2′-hydroxyphenyl)benzothiazole (HBT) appendage capable of rapid excited-state intramolecular proton transfer (ESIPT). The ESIPT effect also provided two unique advantages: It assisted the deprotonation of the pHP group for faster release, and it was accompanied by a distinct fluorescence color change upon photorelease. In vitro studies showed that the p-hydroxyphenacyl-benzothiazole-chlorambucil conjugate presents excellent properties, such as real-time monitoring, photoregulated drug delivery, and biocompatibility.

Synthesis method of salbutamol sulfate intermediate

-

Paragraph 0028-0032, (2021/05/05)

The invention discloses a synthesis method of a salbutamol sulfate intermediate, which comprises the following steps: by taking salicylaldehyde as a raw material, carrying out three-step reaction of Friedel-Crafts acylation, reduction, propylidene protection and N alkylation, and obtaining the target product salbutamol intermediate with the reaction yield of more than 60% in each step. The synthesis method of the salbutamol sulfate intermediate has the advantages of few reaction steps, simple post-treatment and high product purity.

Light triggered uncaging of hydrogen sulfide (H2S) with real-time monitoring

Venkatesh, Yarra,Das, Joyjyoti,Chaudhuri, Amrita,Karmakar, Anupam,Maiti, Tapas K.,Singh, N. D. Pradeep

supporting information, p. 3106 - 3109 (2018/03/28)

An ESIPT based light activated hydrogen sulfide (H2S) donor using a p-hydroxyphenacyl phototrigger has been developed. The unique feature of our H2S donor system is that it provides real-time monitoring of H2S release by a non-invasive fluorescence colour change approach.

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