1158075-65-0Relevant academic research and scientific papers
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl) benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor
Faghih, Ramin,Gopalakrishnan, Sujatha M.,Gronlien, Jens Halvard,Malysz, John,Briggs, Clark A.,Wetterstrand, Caroline,Ween, Hilde,Curtis, Michael P.,Sarris, Kathy A.,Gfesser, Gregory A.,El-Kouhen, Rachid,Robb, Holly M.,Radek, Richard J.,Marsh, Kennan C.,Bunnelle, William H.,Gopalakrishnan, Murali
, p. 3377 - 3384 (2009)
The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of α7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), a novel type II PAM with good potency and selectivity. Compound 19
