1158083-38-5Relevant academic research and scientific papers
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production
Crooks, Peter A.,Fu, Qiang,Gao, Zhengya,Hendrickson, Howard,Liu, Xingui,Song, Lin,Zhang, Peiyi,Zhang, Xuan,Zheng, Guangrong,Zhou, Daohong
, (2020)
δ-tocotrienol (DT3), a member of vitamin E family, has been shown to have a potent radio-protective effect. However, its application as a radioprotectant is limited, at least in part, by its short plasma elimination half-life and low bioavailability. In a
ω-Di-(trideuteromethyl)-tocotrienols as probes for membrane orientation and dynamics of tocotrienols
West, Ryan,Wang, Yongsheng,Atkinson, Jeffrey
, p. 413 - 418 (2008)
The study of the dynamic and structural role of lipids in membranes is commonly accomplished using 2H NMR and neutron diffraction. This necessarily requires the availability of specifically deuterated lipids. Our interest in the behaviour of to
Metabolism of geraniol in grape berry mesocarp of Vitis vinifera L. cv. Scheurebe: Demonstration of stereoselective reduction, E/Z-isomerization, oxidation and glycosylation
Luan, Fang,Mosandl, Armin,Muench, Andreas,Wuest, Matthias
, p. 295 - 303 (2005)
The metabolism of deuterium labeled geraniol in grape mesocarp of Vitis vinifera L. cv. Scheurebe was studied by in vivo-feeding experiments. Stereoselective reduction to (S)-citronellol, E/Z-isomerization to nerol, oxidation to neral/geranial and glycosylation of the corresponding monoterpene alcohols could be demonstrated. Time course studies including the determination of conversion rates revealed that the activity of these secondary transformations of monoterpenes is dependent on the ripening stage and can be distinguished from the development of the primary monoterpene synthase activities by the sharp increase at the end of the ripening period. The stereoselective biosynthesis of the potent odorant cis-(2S,4R)-rose oxide from labeled geraniol in grape berry mesocarp is demonstrated as well. Since (S)-citronellol is the precursor of cis-(2S,4R)-rose oxide it can be concluded that especially the last part of the ripening period is important for the generation of this potent odorant. This finding confirms the conclusion that a higher concentration of flavor compounds could be established in the berries by leaving the fruit on the vine for extended periods.
Iridoid Sex Pheromone Biosynthesis in Aphids Mimics Iridoid-Producing Plants
Partridge, Suzanne J.,Withall, David M.,Caulfield, John C.,Pickett, John A.,Stockman, Robert A.,Oldham, Neil J.,Birkett, Michael A.
supporting information, p. 7231 - 7234 (2021/04/21)
Biosynthesis of (1R,4aS,7S,7aR)-nepetalactol (1) and (4aS,7S,7aR)-nepetalactone (2) in plants involves iridoid synthase (ISY), an atypical reductive cyclase that catalyses the reduction of 8-oxogeranial into the reactive enol of (S)-8-oxocitronellal, and cyclization of this enol intermediate, either non-enzymatically or by a nepetalactol-related short chain dehydrogenase enzyme (NEPS) that yields the nepetalactols. In this study, we investigated the biosynthesis in vivo of 1 and 2 in the pea aphid, Acyrthosiphon pisum, using a library of isotopically-labelled monoterpenoids as molecular probes. Topical application of deuterium-labelled probes synthesized from geraniol and nerol resulted in production of 2H4?lactol 1 and 2H4?lactone 2. However, deuterium incorporation was not evident using labelled probes synthesized from (S)-citronellol. These results suggest that iridoid biosynthesis in animals, specifically aphids, may follow a broadly similar route to that characterised for plants.
DEUTERATED EPI-743
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Paragraph 165, (2017/06/12)
This invention relates to novel α-tocotrienol quinones of Formula I: (I), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treat
Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines
Buchy, Eric,Vukosavljevic, Branko,Windbergs, Maike,Sobot, Dunja,Dejean, Camille,Mura, Simona,Couvreur, Patrick,Desma?le, Didier
, p. 1127 - 1135 (2016/07/06)
The synthesis of ω-di-(trideuteromethyl)-trisnorsqualenic acid has been achieved from natural squalene. The synthesis features the use of a Shapiro reaction of acetone-d6 trisylhydrazone as a key step to implement the terminal isopropylidene-d
