1158279-20-9 Usage
Biological Activity
hlcl-61 is a prmt5 inhibitor.aberrant methylation of protein arginine residues mediated by protein arginine methyltransferase (prmt) enzymes is reported to be linked to cancer. prmts are a family of proteins with 11 known members catalyzing the transfer of methyl group(s) to the guanidine nitrogen atoms of peptide arginine residues. prmt5 has multiple substrates including histones and other non-chromatin proteins and has been gained attention for cancer therapy.
in vitro
in previous study, hlcl-61 showed no inhibitory activity against prmt1, prmt4, and type ii prmt family members, therefore demonstrating its specificity for prmt5. hlcl-61 also showed effective inhibition of symmetric arginine dimethylation of histones h3 and h4, starting at 12 h posttreatment and persisting for 48 h. moreover, the treatment of aml cell lines and primary blasts with hlcl-61 led to the decrease of cell viability. in addition, hlcl-61-treated aml cell lines and patient samples had induction of differentiation as demonstrated by dose-dependent increases in the expression of cd11b. furthermore, prmt5 inhibition caused by hlcl-61 treatment led to a decrease in mv4-11 cells [1].
references
[1] tarighat ss et al. the dual epigenetic role of prmt5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. leukemia. 2016 apr;30(4):789-99.
Check Digit Verification of cas no
The CAS Registry Mumber 1158279-20-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,8,2,7 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1158279-20:
(9*1)+(8*1)+(7*5)+(6*8)+(5*2)+(4*7)+(3*9)+(2*2)+(1*0)=169
169 % 10 = 9
So 1158279-20-9 is a valid CAS Registry Number.