1158347-73-9Relevant articles and documents
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity
Lavieri, Robert,Scott, Sarah A.,Lewis, Jana A.,Selvy, Paige E.,Armstrong, Michelle D.,Alex Brown,Lindsley, Craig W.
experimental part, p. 2240 - 2243 (2009/12/07)
This Letter describes the synthesis and structure-activity relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of a 1,3,8-triazaspiro[4,5]decan-4-one privileged structure, PLD inhibitors with nanomolar potency and an unp