1158445-88-5

Basic information

• Product Name: C₁₇H₂₃NO₂
• Synonyms: C₁₇H₂₃NO₂
• CAS NO: 1158445-88-5
• Molecular Weight: 273.375
• Mol File: 1158445-88-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₃NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₃NO₂(1158445-88-5)
• EPA Substance Registry System: C₁₇H₂₃NO₂(1158445-88-5)

Safety Data

• Hazardous Substances Data: 1158445-88-5(Hazardous Substances Data)

Upstream product

• 1158445-86-3 CF₃O₃S^(1-)*C₁₇H₂₄NO₂⁽¹⁺⁾ 
• 459426-36-9 ethyl 1-((S)-1-phenylethyl)azetidine-2-carboxylate 
• 106-95-6 allyl bromide 
• 36847-51-5 ethyl 2,4-dibromobutyrate 

Relevant articles and documents

Base-promoted diastereoselective α-alkylation of borane: N -((S)-1′-phenylethyl)azetidine-2-carboxylic acid ester complexes

The base-promoted α-alkylation of N-((S)-1-phenylethyl)azetidine-2-carboxylic acid esters 1 was investigated. The use of diastereomerically pure borane complexes 3 as substrates, which are easily prepared from 1, dramatically improved the yields and diastereoselectivities of α-alkylated products 2. For example, the treatment of tert-butyl ester (1S,2S,1′S)-3a with 2.4 equivalents of lithium bis(trimethysilyl)amide (LiHMDS) at 0 °C followed by 2.6 equivalents of benzyl bromide afforded α-benzylated (2S,1′S)-2aa in 90% yield as almost a single diastereomer. Our method enables the production of optically active α-substituted azetidine-2-carboxylic acid esters starting from commercially available (S)-1-phenylethylamine, which is one of the least expensive chiral compounds.