1158680-98-8

Basic information

• Product Name: 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester
• Synonyms: 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester;1-(tetrahydro-2H-pyran-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
• CAS NO: 1158680-98-8
• Molecular Formula: C₁₈H₂₅BN₂O₃
• Molecular Weight: 347.23692
• Mol File: 1158680-98-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester(1158680-98-8)
• EPA Substance Registry System: 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester(1158680-98-8)

Safety Data

• Hazardous Substances Data: 1158680-98-8(Hazardous Substances Data)

Usage

General Description

1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester is a chemical compound that belongs to the class of boronic acid pinacol esters. It is a valuable reagent in organic synthesis, particularly in the field of medicinal chemistry and drug discovery. 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester is used as a building block for the synthesis of various pharmaceuticals and biologically active molecules. The presence of the boronic acid group makes it a versatile reagent for the formation of carbon-carbon and carbon-heteroatom bonds through Suzuki-Miyaura cross-coupling reactions. Additionally, the tetrahydro-2H-pyran and indazol moieties make it a unique and valuable intermediate for the synthesis of complex molecules with potential biological activities. Overall, 1-(tetrahydro-2H-pyran)-1H-indazol-6-boronic acid pinacol ester is an important chemical compound with diverse applications in organic synthesis and drug discovery.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 79762-54-2 6-bromo-1H-indazole 
• 1158680-88-6 6-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 
• 73183-34-3 bis(pinacol)diborane 
• 142-68-7 TETRAHYDROPYRANE 
• 937049-58-6 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 

Downstream Products

• 1158681-07-2 C₁₉H₂₀N₂O₂ 

Relevant articles and documents

N-HETEROARYL INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

COMPOUNDS

Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

FUSED PYRIMIDINE COMPOUND, AND PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USES THEREOF

Disclosed are a fused pyrimidine compound as represented by formula I, pharmaceutically acceptable salt, hydrate or solvate thereof, an optical isomer or a prodrug thereof, as well as a preparation method, an intermediate, a composition and uses thereof. The fused pyrimidine compound according to the present invention can inhibit activity of PI3 kinase, and can be used to treat diseases such as cancer caused by abnormal activity of the PI3 kinase, or can be used to prepare medicine for treating these diseases.