1158726-75-0Relevant academic research and scientific papers
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II)
Li, Xun,Wang, Yazhou,Wu, Jifeng,Li, Yonggang,Wang, Qiang,Xu, Wenfang
scheme or table, p. 3061 - 3071 (2009/09/06)
As our ongoing work, a series of peptidomimetic l-iso-glutamine derivatives derived from antineoplaston AS2-5 scaffold were prepared and their APN/CD13 and MMP-2 inhibitory activities were evaluated hereby. The results displayed that these compounds exhibited selective inhibition against APN as compared with MMP-2, with IC50 values in micromole range. Compounds A1 and A2 showed comparable APN inhibitory activities than the positive control bestatin.
