1158728-80-3 Usage
Description
4'-C-azido-2'-deoxy-2'-fluoro-uridine is a chemical compound belonging to the class of nucleoside analogues. It is a modified form of uridine, characterized by the presence of an azido group at the 4'-carbon position and a fluoro group at the 2'-carbon position. This unique structural modification endows it with potential antiviral and anticancer activities, as well as applications in nucleic acid labeling and bioconjugation studies. As a promising candidate in medicinal chemistry and drug discovery, 4'-C-azido-2'-deoxy-2'-fluoro-uridine is of significant interest for its distinctive properties and potential biological impacts.
Uses
Used in Pharmaceutical Industry:
4'-C-azido-2'-deoxy-2'-fluoro-uridine is used as a nucleoside analogue for its potential antiviral and anticancer activities. 4'-C-azido-2'-deoxy-2'-fluoro-uridine's unique structural features allow it to interfere with viral replication and cancer cell proliferation, making it a valuable asset in the development of new therapeutic agents.
Used in Biotechnology Industry:
In the biotechnology sector, 4'-C-azido-2'-deoxy-2'-fluoro-uridine serves as a key component in nucleic acid labeling. Its incorporation into nucleic acid sequences enables the tracking and detection of specific genetic material, which is crucial for various molecular biology techniques and research applications.
Used in Research and Development:
4'-C-azido-2'-deoxy-2'-fluoro-uridine is utilized in bioconjugation studies, where it can be linked to other molecules to create hybrid compounds with novel properties. This application is vital for the advancement of targeted drug delivery systems and the development of new diagnostic tools in medical research.
Overall, 4'-C-azido-2'-deoxy-2'-fluoro-uridine's multifaceted applications across different industries underscore its importance in the fields of medicine, biotechnology, and scientific research, highlighting its potential to contribute to innovative solutions in healthcare and life sciences.
Check Digit Verification of cas no
The CAS Registry Mumber 1158728-80-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,8,7,2 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1158728-80:
(9*1)+(8*1)+(7*5)+(6*8)+(5*7)+(4*2)+(3*8)+(2*8)+(1*0)=183
183 % 10 = 3
So 1158728-80-3 is a valid CAS Registry Number.
1158728-80-3Relevant articles and documents
4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION
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Paragraph 0329, (2016/09/12)
The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by Filoviruses such as Ebolavirus.
Azido nucleosides and nucleotide analogs
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Page/Page column 96; 98, (2016/06/13)
Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
