1158749-94-0

Basic information

• Product Name: tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate
• Synonyms: tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate;2-oxo-1,8-Diazaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 1158749-94-0
• Molecular Formula: C13H22N2O3
• Molecular Weight: 254.32538
• Mol File: 1158749-94-0.mol

Chemical Properties

• Boiling Point: 424.9±38.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.21±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate(1158749-94-0)
• EPA Substance Registry System: tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate(1158749-94-0)

Safety Data

• Hazardous Substances Data: 1158749-94-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structural features, including the bicyclic ring system and the carboxylate ester functionality, make it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate is used as a potential lead compound for the development of new drugs. Its unique structure and functional groups can be exploited to design and synthesize novel bioactive molecules with potential therapeutic applications. tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate's stability and reactivity can be further explored to optimize its pharmaceutical properties and enhance its efficacy in treating various diseases.

Upstream product

• 1234481-62-9 C₁₄H₂₄N₂O₆ 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 

Downstream Products

• 1389313-57-8 1,8-diazaspiro[4.5]decan-2-one hydrochloride 
• 1588959-06-1 8-(2-methoxy-6-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-1,8-diazaspiro[4.5]decan-2-one 
• 1588959-04-9 8-(6-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-1,8-diazaspiro[4.5]decan-2-one 

Relevant articles and documents

N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc.

Photocatalytic α-Tertiary Amine Synthesis via C?H Alkylation of Unmasked Primary Amines

A practical, catalytic entry to α,α,α-trisubstituted (α-tertiary) primary amines by C?H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100 percent atom-economy. Our strategy, which uses an organic photocatalyst in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, provides a direct synthesis of α-tertiary amines, or their corresponding γ-lactams. We anticipate that this methodology will inspire new retrosynthetic disconnections for substituted amine derivatives in organic synthesis, and particularly for challenging α-tertiary primary amines.