1158751-97-3 Usage
Indole derivative
The compound is derived from the indole structure, which is a bicyclic aromatic organic compound.
Dimethyl substitution
3 and 3' positions
Two methyl groups (CH3) are attached to the 3 and 3' positions of the indole ring, resulting in a dimethyl substitution.
Iodine substitution
6 position
An iodine atom (I) is attached to the 6 position of the indole ring, resulting in an iodine substitution.
Unique structure
The compound has a distinct structure due to the presence of the dimethyl and iodine substitutions on the indole ring.
Potential pharmacological properties
The compound may exhibit pharmacological activity, making it a subject of interest in pharmaceutical research.
Organic synthesis and pharmaceutical research
The compound is often used in organic synthesis and pharmaceutical research due to its unique structure and potential pharmacological properties.
Handling precautions
It is important to handle 2,3-dihydro-6-iodo-3,3-dimethyl-1H-Indole with care, as it may have potential hazards.
Controlled laboratory setting
The compound should be used in a controlled laboratory setting to ensure safety and proper handling.
Check Digit Verification of cas no
The CAS Registry Mumber 1158751-97-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,8,7,5 and 1 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1158751-97:
(9*1)+(8*1)+(7*5)+(6*8)+(5*7)+(4*5)+(3*1)+(2*9)+(1*7)=183
183 % 10 = 3
So 1158751-97-3 is a valid CAS Registry Number.
1158751-97-3Relevant academic research and scientific papers
Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors
Gonzalez-Lopez De Turiso, Felix,Shin, Youngsook,Brown, Matthew,Cardozo, Mario,Chen, Yi,Fong, David,Hao, Xiaolin,He, Xiao,Henne, Kirk,Hu, Yi-Ling,Johnson, Michael G.,Kohn, Todd,Lohman, Julia,McBride, Helen J.,McGee, Lawrence R.,Medina, Julio C.,Metz, Daniela,Miner, Kent,Mohn, Deanna,Pattaropong, Vatee,Seganish, Jennifer,Simard, Jillian L.,Wannberg, Sharon,Whittington, Douglas A.,Yu, Gang,Cushing, Timothy D.
, p. 7667 - 7685 (2012/10/29)
Structure-based rational design led to the synthesis of a novel series of potent PI3K inhibitors. The optimized pyrrolopyridine analogue 63 was a potent and selective PI3Kβ/δ dual inhibitor that displayed suitable physicochemical properties and pharmacokinetic profile for animal studies. Analogue 63 was found to be efficacious in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis (CIA) disease model of rheumatoid arthritis. These studies highlight the potential therapeutic value of inhibiting both the PI3Kβ and δ isoforms in the treatment of a number of inflammatory diseases.
