115879-11-3Relevant academic research and scientific papers
Stereoselective oxirane formation by reaction of diazomethane on 1-fluoro-3--3-phenylpropan-2-one
Bravo, Pierfrancesco,Frigerio, Massimo,Fronza, Giovanni,Soloshonok, Vadim,Viani, Fiorenza,et al.
, p. 1769 - 1779 (2007/10/02)
(2S,2'R,RS)-2-(Fluoromethyl)-2-methyl>oxirane (4) was obtained in high chemical yield and with high diastereoselectivity by reacting diazomethane with pure (3R,RS)-1-fluoro-3-(4-methylphenyl)sulfin
NEW CHIRONS FOR THE SYNTHESIS OF FLUORINE-CONTAINING COMPOUNDS. AN EFFICIENT ENTRANCE TO α-MONO- AND POLY-FLUORO KETONES HAVING A CHIRAL α'-SULPHINYL SUBSTITUENT
Bravo, Pierfrancesco,Piovosi, Elena,Resnati, Giuseppe,Munari, Sergio De
, p. 115 - 122 (2007/10/02)
The lithium derivatives of optically pure alkyl p-tolyl sulphoxides, having both the R and S absolute configurations at the sulphur atom, have been condensed with the esters of mono- and poly-fluorocarboxylic acids to give several mono- and poly-fluoro ketones with a chiral sulphinyl substituent.The compounds having an alkyl residue on the α or α' position of the ketone group have also been obtained through alkylation of the di-, or mono-anion of the unsubstituted terms.Products chiral only at the sulphur atom, at the sulphur and the fluorinated carbon atom, or at the sulphur and the sulphinyl-substituted carbon have been obtained as single pure enantiomers.
