1158795-64-2Relevant academic research and scientific papers
Potent cytotoxic C-11 modified geldanamycin analogues
Tian, Zong-Qiang,Wang, Zhan,MacMillan, Karen S.,Zhou, Yiqing,Carreras, Christopher W.,Mueller, Thomas,Myles, David C.,Liu, Yaoquan
experimental part, p. 3265 - 3273 (2010/03/26)
17-Allylamino-17-demethoxygeldanamycin (17-AAG) inhibits the activity of Hsp90, an important target for treatment of cancers. In an effort to identify analogues of geldanamycin (GDM) with properties superior to those of 17-AAG, we synthesized C-11 modifie
