115880-04-1

Basic information

• Product Name: 2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER
• Synonyms: 2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER;Acetic acid, 2-(4-phenylcyclohexylidene)-, ethyl ester;Ethyl 2-(4-phenylcyclohexylidene)acetate
• CAS NO: 115880-04-1
• Molecular Formula: C₁₆H₂₀O₂
• Molecular Weight: 244.3288
• Mol File: 115880-04-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 355.584°C at 760 mmHg
• Flash Point: 199.893°C
• Appearance: /
• Density: 1.089g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER(115880-04-1)
• EPA Substance Registry System: 2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER(115880-04-1)

Safety Data

• Hazardous Substances Data: 115880-04-1(Hazardous Substances Data)

Usage

General Description

2-(4-phenylcyclohexylidene)-acetic acid ethyl ester is a chemical compound with the molecular formula C17H20O2. It is an ethyl ester of a derivative of acetic acid and is also known as 4-phenylcyclohexylidenacetic acid ethyl ester. 2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER is a liquid with a molecular weight of 256.34 g/mol. It is commonly used as a reagent in organic synthesis and as a precursor for the synthesis of other compounds. Additionally, it has potential applications in pharmaceutical research and development due to its structural properties.

InChI:InChI=1/C16H20O2/c1-2-18-16(17)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-7,12,15H,2,8-11H2,1H3/b13-12-

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 92-68-2 4-cyclohexylcyclohexanone 
• 64-17-5 ethanol 
• 204014-40-4 2-(4-phenylcyclohexylidene)acetic acid 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 108062-27-7 2-(4-phenylcyclohexyl)acetic acid 
• 52092-29-2 (trans)-2-(4-phenylcyclohexyl)acetic acid 
• 148962-93-0 (cis)-2-(4-phenylcyclohexyl)acetic acid 
• 701232-20-4 2-(trans)-(4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b]-[1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid 
• 1593076-96-0 C₂₂H₂₅N₅O 
• 701232-19-1 C₂₄H₃₀N₄O₃ 
• 701232-18-0 ethyl 2-(4-(4-(2-bromo-2-methylpropanoyl)phenyl)cyclohexyl)acetate 
• 1071938-98-1 C₁₄H₁₈O 

Relevant articles and documents

Highly regioselective Wittig reactions of cyclic ketones with a stabilized phosphorus ylide under controlled microwave heating

Significant base and temperature effects on the Wittig reactions of cyclohexanones with (carbethoxymethylene)triphenylphosphorane under microwave irradiation were observed. For the Wittig reactions carried out in a domestic microwave oven under solvent-free conditions, the initially formed exo-olefin products isomerized into the thermodynamically more stable endo-olefins due to uncontrolled high reaction temperature. In sharp contrast, under controlled microwave heating, both exo- and endo-olefins have been selectively synthesized by accurately regulating the reaction temperature with or without a base.

Acid-promoted olefination of ketones by an iron(III) porphyrin complex

(Matrix presented) The acid-promoted olefination of unactivated ketones with diazo reagents in the presence of triphenylphosphine can be catalyzed by the commercially available iron(III) porphyrin complex Fe(TPP)Cl. The reactions were effectively carried out under mild conditions in a one-pot fashion with the use of a stoichiometric diazo reagents and substoichiometric benzoic acid. Examples include aromatic, aliphatic, cyclic, and unsaturated ketones with ethyl diazoacetate or tert-butyl diazoacetate.

Polycyclic compound and its pharmaceutical composition and application

The invention discloses a polycyclic compound and its preparation method, pharmaceutical composition and application. The polycyclic compound (I) and its isomer, prodrug, stable isotope derivative ora pharmaceutically acceptable salt have the structure shown in the description. The polycyclic compound has good IDO1 inhibitory effects and can be used for effectively treating, alleviating and/or preventing various related diseases such as tumors and infectious diseases caused by immunosuppression.

IMMUNOREGULATORY AGENTS

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases,