1158838-41-5

Basic information

• Product Name: 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide
• Synonyms: 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide;4-[(2-Chloro-5-fluoro-4-pyrimidinyl)amino]-N-(2-chlorophenyl)benzamide
• CAS NO: 1158838-41-5
• Molecular Formula: C₁₇H₁₁Cl₂FN₄O
• Molecular Weight: 377.1998432
• Mol File: 1158838-41-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide(1158838-41-5)
• EPA Substance Registry System: 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide(1158838-41-5)

Safety Data

• Hazardous Substances Data: 1158838-41-5(Hazardous Substances Data)

Usage

General Description

The chemical 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide is a compound with a complex molecular structure. It contains a pyrimidinylamine group, a benzamide group, and chloro and fluoro substituents. 4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide may have potential medicinal or pharmaceutical applications due to its structural features, and it could be used in the development of new drugs or as a research tool in biochemistry. Further studies are necessary to fully understand its properties and potential uses.

Upstream product

• 95-51-2 o-chloroaniline 
• 66493-39-8 4-(N-tert-butoxycarbonyl)aminobenzoic acid 
• 888-79-9 4-amino-N-(2-chlorophenyl)benzamide 
• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 

Downstream Products

• 1158838-42-6 2-(4-(4-(4-(2-chlorophenylcarbamoyl)phenylamino)-5-fluoropyrimidin-2-ylamino)phenyl)acetic acid 
• 1158838-49-3 N-(2-chlorophenyl)-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide 

Relevant articles and documents

Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors

The Aurora kinases are a family of serine/threonine kinases that interact with components of the mitotic apparatus and serve as potential therapeutic targets in oncology. Herein, we reported a series of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl with selective inhibition of Aurora A in either enzymatic assays or cellular phenotypic assays, and displaying more potent anti-proliferation compared with that of VX-680. The most potent compound 10a forms better interaction with Aurora A than Aurora B in molecular docking. Mechanistic studies revealed that 10a disrupt the spindle formation, block the cell cycle progression in the G2/M phase and induce apoptosis in HeLa cell. These results suggested that the produced series of compounds are potential anticancer agents for further development as selective Aurora A inhibitors.