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1158838-42-6

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1158838-42-6 Usage

Uses

2-(4-(4-(4-(2-Chlorophenylcarbamoyl)phenylamino)-5-fluoropyrimidin-2-ylamino)phenyl)acetic Acid is used as a reactant in the synthesis of bisanilinopyrimidine Aurora A inhibitors with high selectivity.

Check Digit Verification of cas no

The CAS Registry Mumber 1158838-42-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,8,8,3 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1158838-42:
(9*1)+(8*1)+(7*5)+(6*8)+(5*8)+(4*3)+(3*8)+(2*4)+(1*2)=186
186 % 10 = 6
So 1158838-42-6 is a valid CAS Registry Number.

1158838-42-6Relevant articles and documents

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B

Aliagas-Martin, Ignacio,Burdick, Dan,Corson, Laura,Dotson, Jennafer,Drummond, Jason,Fields, Carter,Huang, Oscar W.,Hunsaker, Thomas,Kleinheinz, Tracy,Krueger, Elaine,Liang, Jun,Moffat, John,Phillips, Gail,Pulk, Rebecca,Rawson, Thomas E.,Ultsch, Mark,Walker, Leslie,Wiesmann, Christian,Zhang, Birong,Zhu, Bing-Yan,Cochran, Andrea G.

experimental part, p. 3300 - 3307 (2010/03/24)

The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are now under clinical investigation. However, the ATP-binding sites

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