1158838-43-7 Usage
General Description
Aurora A inhibitor II is a small molecule compound that specifically targets and inhibits the activity of the Aurora A kinase enzyme. This enzyme is known to play a crucial role in regulating cell division, making it an attractive target for cancer therapy. By inhibiting Aurora A kinase, this compound has the potential to disrupt the cell cycle and induce cell death in cancer cells. Additionally, it has been shown to have potent anti-tumor activity in preclinical studies, making it a promising candidate for the development of new cancer treatments. Aurora A inhibitor II has the potential to be used in combination with other cancer drugs to improve their effectiveness and reduce the development of drug resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 1158838-43-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,8,8,3 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1158838-43:
(9*1)+(8*1)+(7*5)+(6*8)+(5*8)+(4*3)+(3*8)+(2*4)+(1*3)=187
187 % 10 = 7
So 1158838-43-7 is a valid CAS Registry Number.
1158838-43-7Relevant articles and documents
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
Aliagas-Martin, Ignacio,Burdick, Dan,Corson, Laura,Dotson, Jennafer,Drummond, Jason,Fields, Carter,Huang, Oscar W.,Hunsaker, Thomas,Kleinheinz, Tracy,Krueger, Elaine,Liang, Jun,Moffat, John,Phillips, Gail,Pulk, Rebecca,Rawson, Thomas E.,Ultsch, Mark,Walker, Leslie,Wiesmann, Christian,Zhang, Birong,Zhu, Bing-Yan,Cochran, Andrea G.
experimental part, p. 3300 - 3307 (2010/03/24)
The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are now under clinical investigation. However, the ATP-binding sites
