115887-72-4

Basic information

• Product Name: 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester
• CAS NO: 115887-72-4
• Molecular Weight: 485.54
• Mol File: 115887-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester(115887-72-4)
• EPA Substance Registry System: 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester(115887-72-4)

Safety Data

• Hazardous Substances Data: 115887-72-4(Hazardous Substances Data)

Upstream product

• 110202-57-8 methyl 4-<2-(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoate 
• 101810-74-6 2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carboxaldehyde 
• 1253-46-9 4-methoxycarbonylbenzyltriphenylphosphonium bromide 
• 23150-65-4 dimethyl glutamate hydrochloride 
• 110202-62-5 dimethyl N-<4-<2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoyl>-L-glutamate 
• 110202-61-4 4-<2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoic acid 

Relevant articles and documents

Synthesis and Antifolate Activity of 5-Methyl-5,10-dideaza Analogues of Aminopterin and Folic Acid and an Alternative Synthesis of 5,10-Dideazatetrahydrofolic Acid, a Potent Inhibitor of Glycinamide Ribonucleotide Formyltransferase

The title compounds were prepared in extensions of a general synthetic approach used earlier to prepare 5-alkyl-5-deaza analogues of classical antifolates.Wittig condensation of 2,4-diaminopyridopyrimidine-6-carboxaldehyde (2a) and its 5-methyl ana