1158951-55-3Relevant academic research and scientific papers
Concise synthesis of capuramycin
Kurosu, Michio,Li, Kai,Crick, Dean C.
supporting information; experimental part, p. 2393 - 2396 (2009/10/23)
A concise total synthesis of capuramycin (1), a promising preclinical TB drug lead, is achieved by high-yield formations of the cyanohydrin 5a and 4″,5″-glycal derivative 12. Capuramycin can be synthesized in eight steps from the uridine building block 5a with 30% overall yield. The synthetic intermediates reported here are useful for generation of analogs to improve pharmacokinetic properties of capuramycin.
