1158976-06-7Relevant articles and documents
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
Foot, Jonathan S.,Deodhar, Mandar,Turner, Craig I.,Yin, Ping,Van Dam, Ellen M.,Silva, Diego G.,Olivieri, Aldo,Holt, Andrew,McDonald, Ian A.
, p. 3935 - 3940 (2012/07/03)
A new class of 3-fluoroallyl amine-based SSAO/VAP-1 inhibitors is reported. These compounds have excellent selectivity over diamine oxidase, MAO-A and MAO-B. Synthesis and SAR studies leading to compound 28 (PXS-4159A) are reported. The pharmacokinetic profile of 28 in the rat, together with activity in a murine model of lung inflammation are also disclosed.
