1158987-01-9Relevant academic research and scientific papers
Meta- and para-difunctionalization of arenes via an ortho-magnesiation and a subsequent sulfoxide-magnesium exchange
Melzig, Laurin,Rauhut, Christian B.,Knochel, Paul
experimental part, p. 1041 - 1048 (2009/12/08)
Highly functionalized 1,2,4-trisubstituted arenes can be prepared on large scale by a two-step sequence, triggered by an aryl sulfoxide group. In the first step, the sulfoxide moiety acts as a metalation directing group, allowing a smooth magnesiation wit
