1159102-07-4Relevant academic research and scientific papers
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors
Morris, Jason C.,Chiche, Johanna,Grellier, Caroline,Lopez, Marie,Bornaghi, Laurent F.,Maresca, Alfonso,Supuran, Claudiu T.,Pouysségur, Jacques,Poulsen, Sally-Ann
experimental part, p. 6905 - 6918 (2011/11/30)
Carbonic anhydrase (CA) enzymes, specifically membrane-bound isozymes CA IX and CA XII, underpin a pH-regulating system that enables hypoxic tumor cell survival and proliferation. CA IX and XII are implicated as potential targets for the development of ne
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties
Singer, Mathilde,Lopez, Marie,Bornaghi, Laurent F.,Innocenti, Alessio,Vullo, Daniela,Supuran, Claudiu T.,Poulsen, Sally-Ann
supporting information; experimental part, p. 2273 - 2276 (2009/12/03)
A series of benzene sulfonamides incorporating thio, sulfinyl or sulfonyl glycoside moieties were synthesized. These glycoconjugates were investigated for their ability to inhibit the enzymatic activity of four human carbonic anhydrases (hCA): isozymes I,
