1159205-41-0Relevant academic research and scientific papers
Efficient synthesis of α-substituted ethylphosphonates via CuH-catalyzed conjugate reduction of terminal alkenylphosphonate
Zhang, Li,Fang, Yewen,Jin, Xiaoping,Guo, Ting,Li, Ruifeng,Li, Yan,Li, Xie,Yang, Yi,Yuan, Meijuan,Tian, Zongming
, p. 4538 - 4541 (2017)
An unprecedented approach toward synthesis of α-substituted ethylphosphonates based on CuH-catalyzed conjugate reduction of vinylphosphonates has been successfully developed. This protocol features mild conditions, broad substrate scope, good functional group compatibility, high overall efficiencies, and easy gram-scale synthesis. The Cu-catalyzed reduction takes place in a highly selective manner on the phosphono substituted C[dbnd]C bond in the case of the reaction of alkenylphosphonates bearing both phosphono and alkyl or aryl substituted alkene moieties. Furthermore, the result of competitive reaction indicates that the Cu-catalyzed conjugate reduction of vinylphosphonate is more challenging and reproducible than the corresponding acrylate's reaction.
Metal-free diimide reduction of alkenylphosphonates: simple and efficient protocol for the synthesis of α-substituted ethylphosphonates
Fang, Yewen,Yuan, Meijuan,Jin, Xiaoping,Zhang, Li,Li, Ruifeng,Yang, Shaoshuai,Fang, Mei
supporting information, p. 1368 - 1371 (2018/03/23)
A simple and straightforward method for the synthesis of α-substituted ethylphosphonates via diimide reduction strategy is described. With K3PO4 or Na2CO3 as the basic additive, a range of terminal alkenylphosph
