115922-43-5Relevant articles and documents
A NOVEL INTERMEDIATE FOR THE PREPARATION OF CEFEPIME
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Page/Page column 5-6, (2008/06/13)
A novel process is disclosed for preparation of cefepime, a cephalosporin antibiotic in two steps comprising of (i) acylation of 7-Amino-3-[(1-methyl-1-pyrrolidinium)methyl]-3-cephem-4-carboxylate hydrochloride (IV) with 4-bromo-2-methoxyimino-3-oxobutyric acid chloride (III) to give 7-(4-bromo-2-methoxyimino-3-oxobutyramido)-3--[(1-methyl-1-pyrrolidinium)methyl]-3-cephem-4-carboxylate (II), (ii) cyclisation of bromo compound II with thiourea to give cefepime (I) and (iii) purification of cefepime.
Method for manufacture of ceftriaxone sodium
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Page/Page column 20-24, (2008/06/13)
An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives
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, (2008/06/13)
A method of producing a 4-halo-2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid ester or amide, which is a synthetic intermediate of value for the production of cephalosporins containing an aminothiazole group, characterized by reacting a 2-(substituted or unsubstituted)-hydroxyimino-3-oxobutyric acid or an ester or amide thereof with a silylating agent and reacting the resulting novel 2-(substituted)hydroxyimino-3-silyloxy-3-butenoic acid ester or amide with a halogenating agent.
