115931-58-3Relevant academic research and scientific papers
4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
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, (2008/06/13)
Novel compounds of the formula STR1 wherein n is an integer from 1 to 4 inclusive; R1 represents a mono- or disubstituent or hydrogen, lower alkyl(C1 -C3), lower alkoxy(C1 -C3), halogen, nitro or trifluoromethyl; R2 is cyano, carboxamido, ethyl carboxylate or halogen; R3 is hydrogen, straight or branched chain lower alkyl(C1 -C3), alkenyl(C2 -c3), alkynyl(C2 -c3), cycloalkyl(C3 -C6), hydroxyalkyl(C1 -C3), dimethylaminoalkyl(C1 -C3), ethoxycarbonyl, alkyl(C1 -C13)carbonyl, 1-(methylethyl)acetamide, cyclohexylethyl, phenyl, mono-or disubstituted phenyl (wherein the phenyl substituent is halogen, trifluoromethyl, lower alkyl(C1 -C3) or lower alkoxy(C1 -C3)), benzyl, mono- or disubstituted benzyl (wherein the benzyl substituent is halogen, lower alkyl(C1 -C3), lower alkoxy(C1 -C3) or trifluoromethyl), benzoyl, 4-methoxybenzoyl, straight or branched chain alkyl(C2 -c3)phenyl, (4-chlorophenyl)phenylmethyl, 1,3-benzodioxol-5-ylmethyl, 1,3-benzodioxol-5-yl, 2-furanylcarbonyl, 2-pyrimidinyl, 2-pyridinyl, 4-morpholinyl-2-oxoethyl, 1-pyrrolidinyl-2-oxoethyl, bis(4-fluorophenyl(methyl, phenylcarboxamido, mono- and disubstituted phenylcarboximido (wherein the phenyl substituents is halogen, trifluoromethyl or lower alkyl(c1 -C3)), adamantanoyl, 3-phenoxypropyl, 4[2-[(5-chloro-2-methoxyphenyl)amino-2-oxo-ethyl], (2-oxo-1-pyrrolidinyl-2-butynyl, phenylmethylcarboxylate, or (2-phenyl-2H-1,2,3-triazol-4-yl(methyl; R4 and R5 are independently hydrogen or lower alkyl(C1 -C3); the dotted line between positions 6 and 7 of the pyrimidine ring represents the presence or absence of a double bond; and the pharmacologically acceptable salts thereof: methods of producing them; therapeutic compositions containing them: and methods of using them to treat anxiety, hypertension, depression, senile dementia, cognitive defects and other neutral behavior problems in warm-blooded animals.
