115932-13-3

Basic information

• Product Name: N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-methylacetamide
• Synonyms: N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-methylacetamide
• CAS NO: 115932-13-3
• Molecular Weight: 291.312
• Mol File: 115932-13-3.mol

Chemical Properties

• CAS DataBase Reference: N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-methylacetamide(115932-13-3)
• EPA Substance Registry System: N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-methylacetamide(115932-13-3)

Safety Data

• Hazardous Substances Data: 115932-13-3(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 115931-01-6 N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]acetamide 
• 74-88-4 methyl iodide 
• 16617-46-2 3-Amino-4-cyanopyrazole 
• 16617-46-2 3-amino-4-cyano-2H-pyrazole 

Downstream Products

• 159224-11-0 N-{3-[3-(N-Hydroxycarbamimidoyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}-N-methyl-acetamide 

Relevant articles and documents

Preparation method of indinplon intermediate

The invention discloses a preparation method of an indanplon intermediate, and belongs to the technical field of medicinal chemistry. According to the invention, simple and cheap m-nitrobenzaldehyde and triethylamine are adopted as raw materials, and a core skeleton of the indeneplon is efficiently and highly selectively constructed through a one-pot cascade reaction without transition metal catalysis, so that generation of isomers is avoided, generation of byproducts is reduced, the yield of a target product is improved, and the synthesis cost is reduced; and subsequently, simple nitro reduction modification is carried out to prepare the indinplon intermediate. In addition, the reaction condition for preparing the indianplon intermediate is mild, operation is simple and convenient, and the method is suitable for industrial production.

Synthesis of some impurities and/or degradation products of zaleplon

(Chemical Equation Presented) Synthesis of several potential impurities and/or degradation products of zaleplon is identified. All the prepared compounds were unambiguously identified by NMR techniques. Spectral characteristics (IR, UV, MS) of these compo

4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines

Novel compounds having the following structural formula: STR1 wherein - - - may represent the presence of a double bond between the C6 and C7 position, Ia, or the absence of a double bond between the C6 and C7 position, Ib; R1 is selected from the group consisting essentially of hydrogen, bromo, chloro, carbamoyl, carboxyl, carboxyalkoxyl where alkoxyl is (C1 -C3), cyano, --CO--CF3, COONa, STR2 --CO--C(CH3)3, and STR3 where X is hydrogen, cyano, halogen and nitro; R2, R4 and R5 may be hydrogen and lower alkyl (C1 -C3); R3 is hydrogen, alkyl (C1 -C3), STR4 where R7 and R8 may be the same or different and are selected from the group consisting essentially of hydrogen, halogen, alkyl (C1 -C3), nitro, alkoxy (C1 -C3), trifluoro-methyl, acetylamino or N-alkylacetylamino where alkyl is (C1 -C3), and R3 may also be selected from a monovalent radical selected from the class consisting essentially of 3-thienyl, 2-pyridinyl, 3-pyridinyl and 4-pyridinyl, either of said pyridinyl radicals being optionally substituted with an alkyl radical R9, where alkyl is (C1 -C4), and the structures of the monovalent 2-pyridinyl, 3-pyridinyl and 4-pyridinyl moieties are depicted respectively as: STR5 R6 is hydrogen or alkyl-(C1 -C3); pharmaceutical compositions of matter containing the above-defined compounds; methods for using the compounds as anxiolytic agents, antihypertensive agents or antidepressant agents in mammals; processes for the preparation of the compounds.