1159489-40-3Relevant academic research and scientific papers
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
Beaulieu, Christian,Isabel, Elise,Fortier, Angélique,Massé, Frédéric,Mellon, Christophe,Méthot, Nathalie,Ndao, Momar,Nicoll-Griffith, Deborah,Lee, Doris,Park, Hyeram,Black, W. Cameron
scheme or table, p. 7444 - 7449 (2011/02/23)
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. The identified inhibitors bearing an amino nitrile warhead in P1 exhibit low nanomolar in vitro potency against cruzipain. Further SAR in P2 por
CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES
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Page/Page column 42-43, (2009/07/03)
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, strongyloidiasis, trichostrongyliasis, trichomoniasis or cestodiasis. Compounds of formula I of the invention are capable of treating and/or preventing the above-identified diseases:
